Washington -Thursday, Federal Officer approved a new type of pain drugs designed to eliminate the risk of addiction and eliminate relevant overdose. Opioid Drugs such as VICODIN and OXYCONTIN.
The United States Food and Pharmaceutical Bureau said that JOURNAVX, a peak pharmaceutical pillar, for short -term pain following surgery and injury.
This is the first new drug approach that treats pain for over 20 years, and provides both opioids and over -the -counter medicines, such as Ibuprofen and acetaminophen. However, the modest effectiveness of the drug and the long development process emphasize the challenges of finding a new way to manage pain.
Peak pharmaceuticals via AP
In two studies for more than 870 patients with acute pain after the feet and abdominal surgery, the vertex drugs brought more easier than dummy tablets, but the combination of general opioid -acetaminophen tablets. It was shown that it was not better.
“It’s not a slum dunk about the effectiveness,” said Michael Shoe, a pharmacist and a painkiller specialist who was not involved in research. “But it’s a slam dunk in that it’s a very different route and an action mechanism, so I think it’s a lot of promises.”
At the top, drug research began research in drugs in the 2000s, when overdose of drugs was rapidly increasing. This was mainly driven by the mass prescription of opioid analgesics for general diseases such as arthritis and back pain. The prescription has dropped sharply in the past decade, and the current wave of the trend of opioids is mainly Illegal FentanylNot a pharmaceutical.
Opioids reduce pain by binding to the receptor of the brain that receives nerve signals from various parts of the body. These chemical interactions also affect the addiction of opioids.
The topic works in different ways and blocks proteins that cause pain signals sent to the brain later.
“The important factor is to block pain signals before reaching the brain when trying to develop drugs that do not have a risk of opioid drugs,” said DAVID ALTSHULER at the top of the year. I talked.
The side effects of drugs generally reported were nausea, constipation, itching, rash, and headaches.
“New medicines are not only essentially different, but also have a side effect profile that does not involve the risk of substance abuse and opioids that do not involve other important side effects,” said the Albannie Medical Center Charles.・ Dr. Awaf said. About the development of drugs.
The first concept that focuses on the signaling protein of pain was born from research, including people in uninhered pain in pain.
Vertex is interested in wall streets with ambitious drug pipelines that accompany the FDA approval of multiple drugs in several forms of chronic pain.
However, Boston’s drug maker stock prices have plunged in December when the results of the peaks of the peak were disappointed. Research has discovered that the drug was not significantly better than Plasbo.
“I think this data reflects the worst scenario of this important pipeline program,” said Brian Abrahams, a biotechnology analyst, in a survey note on investors. He added that the pipeline could be equivalent to billions of dollars in multiple formal pain.
Nevertheless, Vertex executives are planning to move forward in the new late stage of drugs, the theory that different test designs have better results and can open the FDA approval path of chronic pain. I mentioned.
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